Collagen vs Glutathione: What’s The Difference?

Collagen vs Glutathione What's The Difference

When it comes to skin health, a few compounds become essential, among which collagen and glutathione are prominent. Even though both of them are produced naturally in the body, when they are deficient, you need to take supplements.

In this article, we will learn the science behind these basics of healthy skin, how they function and why they are necessary. Also, we will compare collagen and glutathione to get a detailed insight and learn the difference between them. This will help us choose the right supplement for skin’s health.

Difference Between Collagen and Glutathione



Collagen (1) is a type of protein that contributes to skin’s elasticity. It is the building block of the skin that helps give it a healthy, plum, and youthful look. A human body with enough collagen does not sag or age. It is usually found in tendons, ligaments, bone, cartilage, and all connective tissues of the body.

Since collagen is produced naturally in the body, after a certain age its production decreases. At the same time, it breaks down faster, which may cause its deficiency. Other than these, smoking, exposure to UV rays, and sugar and refined carbohydrates intake also reduce collagen production.

As a result, you may experience weakening, wrinkling, and sagging of muscles and skin, and the signs of aging start to become prominent. Additionally, your muscles may ache, cartilage wears off, and mobility may reduce.



While collagen is a protein, glutathione (2) is an antioxidant composed of glycine, L-cysteine, and L-glutamate. Liver and nerve cells produce glutathione naturally in the body. This compound builds tissue and repairs damage by fighting off free radicals.

Besides, glutathione also produces hormones and enzymes that improve the immune system in the body. Regarding its benefits for the skin, the compound is known to brighten the skin.

Usually, glutathione levels drop in the body as we age; however, other factors such as poor diet, stress, infection, weak immune system, etc. also contribute to its depletion. As a result, you may feel fatigued and weak, your muscles may ache, and your immunity may compromise.

Below is the table differentiating collagen vs glutathione in more detail-

Molecular StructureProtein composed of amino acids, primarily glycine, proline, and hydroxyproline.Tripeptide is composed of three amino acids: cysteine, glutamate, and glycine.
FunctionStructural protein provides strength and elasticity to tissues, especially skin, tendons, and ligaments.Antioxidants detoxify cells, support immune function, and help recycle other antioxidants like vitamin C and vitamin E.
ProductionNaturally produced by the body’s fibroblast cells. Can also be derived from animal sources (collagen supplements) or plants.Synthesized in the body from amino acids. It can also be obtained from certain foods or taken as a supplement.
BenefitsSupports skin health by reducing wrinkles and increasing hydration. Also promotes joint health and may aid in muscle repair.Helps to neutralize free radicals, supports liver function, boosts the immune system, and may improve skin tone.
UsageCommonly used in skincare products, supplements (collagen peptides), and medical treatments (e.g., wound healing).Used in supplements, intravenous treatments, and skincare products for its antioxidant properties and potential health benefits.
Side EffectsGenerally considered safe, but possible side effects may include allergic reactions or digestive discomfort in some individuals.Generally well-tolerated, but excessive doses may cause abdominal cramps, diarrhea, or nausea. Individuals with certain medical conditions should consult a healthcare provider before use.
Research StatusExtensive research supporting its role in skin and joint health. Ongoing studies explore its potential in other areas such as bone health and wound healing.Research supports its antioxidant properties and potential benefits for various health conditions. Further studies are needed to fully understand its efficacy and safety in different contexts.

Collagen vs Glutathione- Supplements for Skin

Collagen and glutathione are considered the basics of skin health; therefore, their depletion calls for either increasing the intake of foods rich in them or their supplements.

Collagen Supplementation

Collagen (3) starts depleting in the body in mid-20s, and the signs of its depletion, that is, dull and aging skin, start becoming visible as you reach 30. Likewise, women lose a good amount of collagen after menopause, which makes them wrinkly with sagging skin and fine lines.

In such cases, you can go for cosmetic procedures such as derma fillers that use collagen to fill the depressions and make skin firm. Likewise, you can also start taking collagen supplements.

Glutathione Supplementation

Skin showing signs of melasma after a certain age indicates that the body is lacking in glutathione. In this condition, the body’s melanin production is altered, leading to discolored skin with grey and brown patches. They usually appear on the forehead, chin, and nose.

In such cases, you can start taking foods rich in glutathione (4), such as cruciferous vegetables, spinach, avocados, and turmeric, or its supplement. These come in the form of creams, gels, tablets, etc., that help brighten the skin. Additionally, they boost skin elasticity and improve hydration, giving skin a plump and youthful look.

Can You Take Collagen and Glutathione Together?

Yes, in fact, when collagen and glutathione are used together, they boost each other’s efficacy, giving amazing results. The skin becomes visibly improved, looking more radiant and youthful. There are no side effects of taking them together.


Now that we have compared collagen vs glutathione and provided a detailed information about them, it will be easy to decide which supplement you need to take. Collagen will give structure, strength and support to the skin and glutathione will fight off free radicals and neutralize their adverse effects. Both of them are equally beneficial for skin, especially the mature one, serving different purposes.

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